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semanticscholar.org 📅 2007 📰 Science 🔖 5,905 citations 📄 PDF
CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes
👤 R. Barrangou; C. Fremaux; H. Deveau; Melissa Richards; P. Boyaval; S. Moineau; D. Romero; P. Horvath
DOI: 10.1126/science.1138140
semanticscholar.org 📅 2014 📰 Science 🔖 4,961 citations 📄 PDF
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
👤 Ophir Shalem; Neville E. Sanjana; E. Hartenian; Xi Shi; David A. Scott; T. Mikkelsen; D. Heckl; B. Ebert; D. Root; John G Doench; Feng Zhang
DOI: 10.1126/science.1247005
semanticscholar.org 📅 2013 📰 Cell 🔖 4,694 citations 📄 PDF
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.
👤 Lei S. Qi; Matthew H. Larson; Luke A. Gilbert; J. Doudna; J. Weissman; A. Arkin; W. Lim
DOI: 10.1016/j.cell.2013.02.022
semanticscholar.org 📅 2015 📰 Cell 🔖 4,181 citations 📄 PDF
Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system.
👤 Bernd Zetsche; J. Gootenberg; O. Abudayyeh; I. Slaymaker; K. Makarova; Patrick Essletzbichler; Sara Volz; J. Joung; J. van der Oost; A. Regev; E. Koonin; Feng Zhang
DOI: 10.1016/j.cell.2015.09.038
semanticscholar.org 📅 2018 📰 Science 🔖 3,599 citations 📄 PDF
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
👤 Janice S. Chen; E. Ma; Lucas B. Harrington; Maria Da Costa; Xinran Tian; J. Palefsky; J. Doudna
DOI: 10.1126/science.aar6245
semanticscholar.org 📅 2015 📰 Methods in molecular biology 🔖 3,593 citations
Genome engineering using CRISPR-Cas9 system.
👤 Le Cong; Feng Zhang
DOI: 10.1007/978-1-4939-1862-1_10
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