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semanticscholar.org 📅 2020 📰 Nature Biotechnology 🔖 2,194 citations 📄 PDF
CRISPR-Cas12–based detection of SARS-CoV-2
👤 James P. Broughton; Xianding Deng; Guixia Yu; C. Fasching; V. Servellita; J. Singh; X. Miao; J. Streithorst; A. Granados; A. Sotomayor-González; K. Zorn; Allan Gopez; Elaine D. Hsu; W. Gu; Steve Miller; C. Pan; H. Guevara; D. Wadford; Janice S. Chen; C. Chiu

An outbreak of betacoronavirus severe acute respiratory syndrome (SARS)-CoV-2 began in Wuhan, China in December 2019. COVID-19, the disease associated with SARS-CoV-2 infection, rapidly spread to produce a global pandemic. We report development of a rapid (<40 min), easy-to-implement and accurate CRISPR–Cas12-based…

DOI: 10.1038/s41587-020-0513-4
semanticscholar.org 📅 2019 📰 Chinese Physics C, High Energy Physics & Nuclear Physics 🔖 480 citations 📄 PDF
Future Physics Programme of BESIII
👤 M. Ablikim; M. Achasov; P. Adlarson; S. Ahmed; M. Albrecht; M. Alekseev; A. Amoroso; F. An; Q. An; Y. Bai; O. Bakina; R. Ferroli; Y. Ban; K. Begzsuren; J. Bennett; N. Berger; M. Bertani; D. Bettoni; F. Bianchi; J. Biernat; J. Bloms; I. Boyko; R. Briere; L. Calibbi; H. Cai; X. Cai; A. Calcaterra; G. Cao; N. Cao; S. Cetin; J. Chai; J. Chang; W. Chang; J. Charles; G. Chelkov; Chen; G. Chen; H. Chen; J. Chen; M. Chen; S. Chen; Y. Chen; H. Y. Cheng; W. Cheng; G. Cibinetto; F. Cossio; X. Cui; H. Dai; J. Dai; X. D

There has recently been a dramatic renewal of interest in hadron spectroscopy and charm physics. This renaissance has been driven in part by the discovery of a plethora of charmonium-like XYZ states at BESIII and B factories, and the observation of an intriguing proton-antiproton threshold enhancement and the possibly …

DOI: 10.1088/1674-1137/44/4/040001
semanticscholar.org 📅 2024 📰 Cell 🔖 417 citations 📄 PDF
Past, present, and future of CRISPR genome editing technologies.
👤 Martin Pacesa; O. Pelea; M. Jinek

Genome editing has been a transformative force in the life sciences and human medicine, offering unprecedented opportunities to dissect complex biological processes and treat the underlying causes of many genetic diseases. CRISPR-based technologies, with their remarkable efficiency and easy programmability, stand at th…

DOI: 10.1016/j.cell.2024.01.042
semanticscholar.org 📅 2010 📰 Proceedings of the National Academy of Sciences of the United States of America 🔖 269 citations 📄 PDF
Pressure-induced superconductivity in topological parent compound Bi2Te3
👤 J. Zhang; S. J. Zhang; H. Weng; Wei Zhang; Li Yang; Q. Liu; S. Feng; X. -. Wang; R. Yu; Lipeng Cao; Lin Wang; Wenge Yang; H. Z. Liu; W. Y. Zhao; Shou-Cheng Zhang; X. Dai; Z. Fang; C. Jin

We report a successful observation of pressure-induced superconductivity in a topological compound Bi2Te3 with Tc of ∼3 K between 3 to 6 GPa. The combined high-pressure structure investigations with synchrotron radiation indicated that the superconductivity occurred at the ambient phase without crystal structure phas…

DOI: 10.1073/pnas.1014085108
semanticscholar.org 📅 2023 📰 Journal of Polymer Science 🔖 213 citations 📄 PDF
pH‐responsive polymers for drug delivery: Trends and opportunities
👤 J. Singh; P. Nayak

Polymer science has applications in biomedical engineering, prosthetics, surgical implants, and prospective pharmaceutical excipients for drug delivery. “Intelligent or Smart Polymers” are created for drug targeting either by derivatization of natural polymers or controlled radical polymerization of electrolytes. T…

DOI: 10.1002/pol.20230403
semanticscholar.org 📅 2019 📰 Atmospheric Chemistry and Physics 🔖 194 citations 📄 PDF
Aerosol pH and its driving factors in Beijing
👤 Jing Ding; P. Zhao; Jie Su; Qun Dong; Xiang Du; Yufen Zhang

Abstract. Aerosol acidity plays a key role in secondary aerosol formation. The high-temporal-resolution PM2.5 pH and size-resolved aerosol pH in Beijing were calculated with ISORROPIA II. In 2016–2017, the mean PM2.5 pH (at relative humidity (RH) > 30 %) over four seasons was 4.5±0.7 (winter) > 4.4±1.2 (…

DOI: 10.5194/ACP-19-7939-2019
semanticscholar.org 📅 2025 📰 International Conference on Machine Learning 🔖 129 citations
Flow Q-Learning
👤 Seohong Park; Qiyang Li; Sergey Levine

We present flow Q-learning (FQL), a simple and performant offline reinforcement learning (RL) method that leverages an expressive flow-matching policy to model arbitrarily complex action distributions in data. Training a flow policy with RL is a tricky problem, due to the iterative nature of the action generation proce…

DOI: 10.48550/arXiv.2502.02538
semanticscholar.org 📅 2021 📰 Physical Review Letters 🔖 110 citations 📄 PDF
Observation of a Near-Threshold Structure in the K^{+} Recoil-Mass Spectra in e^{+}e^{-}→K^{+}(D_{s}^{-}D^{*0}+D_{s}^{*-}D^{0}).
👤 B. C. M. Ablikim; M. Achasov; P. Adlarson; S. Ahmed; M. Albrecht; R. Aliberti; A. Amoroso; Q. An; X. Bai; Y. Bai; O. Bakina; R. Ferroli; I. Balossino; Y. Ban; K. Begzsuren; N. Berger; M. Bertani; D. Bettoni; F. Bianchi; J. Biernat; J. Bloms; A. Bortone; I. Boyko; R. Briere; H. Cai; X. Cai; A. Calcaterra; G. Cao; N. Cao; S. Cetin; J. Chang; W. Chang; G. Chelkov; D. Chen; G. Chen; H. Chen; M. Chen; S. Chen; X. Chen; Y. Chen; Z. Chen; W. Cheng; G. Cibinetto; F. Cossio; X. Cui; H. Dai; X. Dai; A. Dbeyssi; R. Bo

We report a study of the processes of e^{+}e^{-}→K^{+}D_{s}^{-}D^{*0} and K^{+}D_{s}^{*-}D^{0} based on e^{+}e^{-} annihilation samples collected with the BESIII detector operating at BEPCII at five center-of-mass energies ranging from 4.628 to 4.698 GeV with a total integrated luminosity of 3.7  fb^{-1}. An exc…

DOI: 10.1103/PhysRevLett.126.102001
semanticscholar.org 📅 2020 📰 Journal of machine learning research 🔖 24 citations
Contextual Stochastic Block Model: Sharp Thresholds and Contiguity
👤 Chen Lu; S. Sen

We study community detection in the contextual stochastic block model arXiv:1807.09596 [cs.SI], arXiv:1607.02675 [stat.ME]. In arXiv:1807.09596 [cs.SI], the second author studied this problem in the setting of sparse graphs with high-dimensional node-covariates. Using the non-rigorous cavity method from statistical phy…

semanticscholar.org 📅 2020 📰 arXiv.org 🔖 19 citations
Identifying the Development and Application of Artificial Intelligence in Scientific Text
👤 James W. Dunham; Jennifer Melot; D. Murdick

We describe a strategy for identifying the universe of research publications relevant to the application and development of artificial intelligence. The approach leverages the arXiv corpus of scientific preprints, in which authors choose subject tags for their papers from a set defined by editors. We compose a function…

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